Fzd7 as a Therapeutic Target for Gastric Cancer

Captopril, a renin-angiotensin system inhibitor, attenuates features of tumor invasion and down-regulates c-myc expression in a mouse model of colorectal cancer liver metastasis

GE Riddiough, T Fifis, KA Walsh, V Muralidharan, C Christophi, BM Tran, E Vincan, MV Perini

2021-06-01

(1) Background: Recent clinical and experimental data suggests that the liver’s regenerative response following partial hepatectom..

Targeting wnt signaling for the treatment of gastric cancer

S Koushyar, AG Powell, E Vincan, TJ Phesse

2020-06-01

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeosta..

The hepatitis B virus pre-core protein P22 activates Wnt signaling

BM Tran, DJ Flanagan, G Ebert, N Warner, H Tran, T Fifis, G Kastrappis, C Christophi, M Pellegrini, J Torresi, TJ Phesse, E Vincan

2020-06-01

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

Wnt signaling in cancer: Not a binary on:off switch

DJ Flanagan, E Vincan, TJ Phesse

2019-12-01

In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment..

The function of lgr5 cells in the gastric antrum does not require fzd7 or myc in vivo

D Flanagan, N Barker, M Ernst, E Vincan, T Phesse

2019-09-01

The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining..

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

J Torresi, BM Tran, D Christiansen, L Earnest-Silveira, RHM Schwab, E Vincan

2019-07-18

BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..

Frizzled-7 is required for Wnt signaling in gastric tumors with and without APC mutations

DJ Flanagan, N Barker, NS Di Costanzo, EA Mason, A Gurney, VS Meniel, S Koushyar, CR Austin, M Ernst, HB Pearson, A Boussioutas, H Clevers, TJ Phesse, E Vincan

2019-03-01

A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of lig..

Wnt signalling in gastrointestinal epithelial stem cells

DJ Flanagan, CR Austin, E Vincan, TJ Phesse

2018-04-01

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is crit..

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells

RHM Schwab, N Amin, DJ Flanagan, TM Johanson, TJ Phesse, E Vincan

2018-03-01

Background: Metastasis underlies most colorectal cancer mortality. Cancer cells spread through the body as single cells or small c..

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

DJ Flanagan, E Vincan, TJ Phesse

2017-12-01

Gastric cancer persists as a frequent and deadly disease that claims over 700 000 lives annually. Gastric cancer is a multifactori..

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan

2017-08-01

The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of ..

Frizzled7: A promising achilles’ heel for targeting the Wnt receptor complex to treat cancer

T Phesse, D Flanagan, E Vincan

2016-05-17

Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate Wnt receptors. Frizzled7 is highly con..